Lainie P Martin Selected Research

Folate Receptor 1

1/2020	Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer.
1/2019	Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody-Drug Conjugate Mirvetuximab Soravtansine.
1/2019	Is Targeting the Folate Receptor in Ovarian Cancer Coming of Age?
10/2018	Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancer.
11/2017	Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion study of the FRα-targeting antibody-drug conjugate mirvetuximab soravtansine.
4/2017	Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study.

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Lainie P Martin Research Topics

Disease

16	Neoplasms (Cancer) 06/2021 - 03/2008
14	Ovarian Neoplasms (Ovarian Cancer) 11/2021 - 03/2014
5	Ovarian Epithelial Carcinoma 11/2021 - 04/2009
5	Carcinoma (Carcinomatosis) 12/2018 - 04/2009
4	Disease Progression 01/2018 - 03/2014
3	Endometrial Neoplasms (Endometrial Cancer) 06/2021 - 02/2015
3	Neutropenia 01/2019 - 12/2012
3	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2018 - 12/2012
2	Anemia 01/2019 - 02/2016
1	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2021
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Stomatitis 01/2019
1	Toxic Optic Neuropathy 01/2019
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2018
1	Adenocarcinoma 12/2018
1	Fallopian Tube Neoplasms 10/2018
1	Edema (Dropsy) 10/2017
1	Nausea 10/2017
1	Fatigue 10/2017
1	Necrosis 01/2016
1	Hypertension (High Blood Pressure) 01/2016
1	Intestinal Fistula 01/2016
1	Lymphoma (Lymphomas) 11/2015
1	Exanthema (Rash) 02/2015
1	Diarrhea 02/2015
1	Turcot syndrome 03/2008

Drug/Important Bio-Agent (IBA)

11	PlatinumIBA 11/2021 - 03/2008
6	mirvetuximab soravtansineIBA 01/2020 - 04/2017
6	Folate Receptor 1IBA 01/2020 - 04/2017
5	Immunoconjugates (Immunoconjugate)IBA 01/2020 - 04/2017
5	Carboplatin (JM8)FDA LinkGeneric 10/2018 - 03/2008
4	Bevacizumab (Avastin)FDA Link 01/2020 - 01/2016
4	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 09/2013
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 11/2021 - 01/2018
3	Monoclonal AntibodiesIBA 01/2020 - 03/2014
3	Pharmaceutical PreparationsIBA 01/2019 - 12/2012
3	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2013
2	TubulinIBA 01/2020 - 04/2017
2	Maytansine (Maitansine)IBA 01/2020 - 04/2017
1	olaparibIBA 11/2021
1	ceralasertibIBA 11/2021
1	Phosphotransferases (Kinase)IBA 11/2021
1	Poly Adenosine Diphosphate RiboseIBA 06/2021
1	GSK2141795IBA 12/2019
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2019
1	trametinibIBA 12/2019
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019
1	Ophthalmic Solutions (Eye Drops)IBA 01/2019
1	MLN 8237IBA 01/2019
1	IpilimumabIBA 12/2018
1	human ALK1-Fc fusion proteinIBA 01/2018
1	veliparibIBA 01/2018
1	Gemcitabine FDA Link 01/2018
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 10/2017
1	Alkaline PhosphataseIBA 10/2017
1	Macrophage Colony-Stimulating FactorIBA 10/2017
1	Biomarkers (Surrogate Marker)IBA 07/2017
1	Cytidine Triphosphate (CTP)IBA 07/2017
1	fosbretabulin (combretastatin A4)IBA 01/2016
1	Tromethamine (Trometamol)FDA Link 01/2016
1	birinapantIBA 11/2015
1	Alanine Transaminase (SGPT)IBA 02/2015
1	Circulating Tumor DNAIBA 02/2015
1	XL147IBA 02/2015
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 02/2015
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 03/2014
1	LigandsIBA 03/2014
1	rilotumumabIBA 03/2014
1	STA 9090IBA 09/2013
1	PM 00104IBA 01/2013
1	Albumin-Bound Paclitaxel FDA Link 12/2012
1	acivicin (AT 125)IBA 12/2012
1	130-nm albumin-bound paclitaxelIBA 12/2012
1	Drug CombinationsIBA 12/2012
1	Biological ProductsIBA 04/2009
1	Cisplatin (Platino)FDA LinkGeneric 03/2008
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 03/2008

Therapy/Procedure

5	Therapeutics 06/2021 - 10/2017
5	Drug Therapy (Chemotherapy) 12/2018 - 04/2009
2	Drug Tapering 01/2019 - 12/2012
1	Immunotherapy 12/2018
1	Intravenous Infusions 01/2013